Actinium-225 production with an electron accelerator

There has been growing clinical evidence of the value targeted alpha therapy for treatment several cancers. The work slowed by lack availability key emitting isotopes, especially Ac-225. It can be produced photonuclear reaction, Ra-226(?,n)Ra-225. Ra-225 decays via beta-decay to Ac-225 with a half-life 14.9 days. This paper will provide technical description radium targets and target chamber that would capable producing yield about 148 GBq (4 Ci) from 10-day irradiation 1 g segmented into two four separate encapsulated at beam power 20 kW. These could milked least three times, yielding nearly is also method reduce activity co-produced Ac-227 values less than few parts per million Monte Carlo code Fluka used model yields support design concept production Ac-227. experimental results Maslov et al. [Radiochemistry 48(2), 195–197 (2006)] reasonable confidence in cross section code.